Apaziquone
id:
apaziquone-307-14483073
title:
Apaziquone
text:
Apaziquone is an indolequinone that is a bioreductive prodrug similar to the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptosis. This activity is preferentially expressed in neoplastic cells. After administration of apaziquone directly into the urinary bladder (intravesically), the drug and its act
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Apaziquone
date created:
date modified:
2022-04-26T01:12:39Z
main entity:
{"identifier":"Q4779259","url":"https://www.wikidata.org/entity/Q4779259"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/3/3d/Apaziquone.svg","width":512,"height":274}
fields total:
13
integrity:
15