Hoesch reaction
id:
hoesch-reaction-307-13151154
title:
Hoesch reaction
text:
The Hoesch reaction or Houben–Hoesch reaction is an organic reaction in which a nitrile reacts with an arene compound to form an aryl ketone. The reaction is a type of Friedel-Crafts acylation with hydrogen chloride and a Lewis acid catalyst. The synthesis of 2,4,6-Trihydroxyacetophenone (THAP) from phloroglucinol is representative: If two-equivalents are added, 2,4-Diacetylphloroglucinol is the product. An imine can be isolated as an intermediate reaction product. The attacking electrophile is
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wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Hoesch_reaction
date created:
date modified:
2023-02-05T10:34:26Z
main entity:
{"identifier":"Q5876506","url":"https://www.wikidata.org/entity/Q5876506"}
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13
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