LR132
id:
lr132-255-11301260
title:
LR132
text:
LR132 or (+)-3,4-dichloro-N-[(1R,2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 2 ± 0.1 nM for the sigma-1 receptor and more than 350 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with LR132 significantly decreases the convulsivity and lethality of cocaine.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/LR132
date created:
date modified:
2023-01-23T11:44:49Z
main entity:
{"identifier":"Q6459781","url":"https://www.wikidata.org/entity/Q6459781"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/3/30/LR132.png","width":1350,"height":801}
fields total:
13
integrity:
15